Tuffs Lab
Recent Publications
2025
G. Y. Díaz, V. A. da Silva, F. Kalantarnia, K. Scheck, S. A. Tschofen, S. W. Tuffs, S. M. Willerth. 2025. Using 3D bioprinting to generate realistic models of wound healing. Advances in Wound Care. https://doi.org/10.1089/wound.2024.0138
A.C. Marple, B. A. Shannon, A. Rishi, L. Estafanos, B. D Armstrong, V. Guariglia-Oropeza, S. W. Tuffs, J. K. McCormick. The Streptococcus pyogenes mannose phosphotransferase system (Man-PTS) influences antimicrobial activity and niche-specific nasopharyngeal infection 2025. Journal of Bacteriology. https://doi.org/10.1128/jb.00492-24
K. Dufresne, S. W. Tuffs, N. R. Walton, K. J. Kasper, I. Mohorovic, F. Hasan, T. Bentall, D. E. Heinrichs, J. Delport, T. S. Mele, J. K. McCormick. 2025. Evidence that staphylococcal superantigens promote within-patient bacterial persistence following post-operative surgical site infection. Infection and Immunity. https://doi.org/10.1128/iai.00407-24
2024
B. A. Shannon, J. R. Hurst, R. S. Flannagan, H. C. Craig, A. Rishi, K. J. Kasper, S. W. Tuffs, D. E. Heinrichs, J. K. McCormick 2024. Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice PLoS pathogens. https://doi.org/10.1371/journal.ppat.1012072
S. W. Tuffs, K. Dufresne, A. Rishi, N. R. Walton, J. K. McCormick. 2024. Novel insights into the immune response to bacterial T cell superantigens. Nature Reviews Immunology. https://doi.org/10.1038/s41577-023-00979-2
C. S. Maduta, S. W. Tuffs, J. K. McCormick, K. Dufresne. 2024. Interplay between Staphylococcus aureus and the vaginal microbiota. Trends In Microbiology. https://doi.org/10.1016/j.tim.2023.12.005
2023
R. C. Kuiack, S. W. Tuffs, K. Dufresne, R. Flick, J. K. McCormick, M. J. McGavin. The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth. Molecular Microbiology. 2023;00:1–14. https://doi.org/10.1111/mmi.15131
2022
J. R. Hurst; B. A. Shannon; H. C. Craig; S. W. Tuffs; J. K. McCormick. The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance. Plos pathogens. 18(11): e1011013. https://doi.org/10.1371/journal.ppat.1011013
D. Chin, R. S. Flannagan, S. W. Tuffs, J. Chan, J. K. McCormick, and D. E. Heinrichs. Staphylococcus lugdunensis uses the Agr regulatory system to resist killing by host innate immune effectors. Infection and Immunity. Vol. 90, No. 10. https://doi.org/10.1128/iai.00099-22
K. Dufresne, V. A. Podskalniy, C. A. Herfst, G. F. M. Lovell, S. Lee, E. N. DeJong, J. K. McCormick, S. W. Tuffs. Glucose mediates niche-specific repression of toxic shock syndrome-1 (TSST-1) through the activity of CcpA during Staphylococcus aureus vaginal colonization. J. Bacteriol. e0026922; https://doi.org/10.1128/jb.00269-22
S. W. Tuffs, M. I. Goncheva, S.X. Xu, H. C. Craig, K. J. Kasper, J. Choi, R. S. Flannagan, S. Kerfoot, D. E. Heinrichs, J. K. McCormick. Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production. PNAS. 119 (8) e2115987119; https://doi.org/10.1073/pnas.2115987119